I2BC External Speaker’s Seminar
Lundi 24 Novembre à 11H00 Salle N2-315 Bat 24
“With a Little Help from Membranes : Secretory Highways in Infection and Development”
Jean-Baptiste Brault
CNRS UMR144 - Cell Biology & Cancer, Institut Curie, Sorbonne-Université, Paris, France
Abstract The endoplasmic reticulum (ER) is the largest membrane-bound organelle in eukaryotic cells and is essential to many cellular functions. It forms the foundation of the secretory pathway through its tight and dynamic interconnection with the Golgi apparatus, and establishes membrane contact sites with most, if not all, other cellular compartments. Many viruses, particularly positive-sense RNA viruses, have evolved strategies to hijack ER membranes to facilitate replication, assembly, and evasion of host defenses. Here, I will present how Influenza A virus - a negative-sense RNA virus with a segmented genome that replicates in the nucleus - co-opts a RAB11A/ATG16L1-driven module to remodel ER membrane architecture and identity, thereby promoting genome egress. In a second part, I will outline my current research as a cell biologist, focusing on how the secretory pathway is organised at the organelle and molecular levels to enable the efficient deposition of extracellular matrix components in radial glial cells - remarkably elongated and polarised neural stem cells that generate the neurons and glial cells of the developing cerebral cortex.
Contact: emmanuelle.quemin@i2bc.paris-saclay.fr
