Speaker: Damien Arnoult, Hospital Paul Brousse, INSERM U 1197
invité par Arnaud Moris
Dr. Damien Arnoult from the Hospital Paul Brousse, INSERM U 1197, will present his work on innate immunity, proteostasis, and mitochondrial stress (see the title and abstract below).
If you want to discuss with Damien after his talk, please contact Arnaud Moris (arnaud.moris@i2bc.paris-saclay.fr) or Inge Kühl (inge.kuhl@i2bc.paris-saclay.fr)
If you want to discuss with Damien after his talk, please contact Arnaud Moris (arnaud.moris@i2bc.paris-saclay.fr) or Inge Kühl (inge.kuhl@i2bc.paris-saclay.fr)
Title : The eIF2a kinase HRI in innate immunity, proteostasis, and mitochondrial stress
"The integrated stress response (ISR) is an evolutionary conserved stress response pathway that leads to a global arrest in translation as well as to the expression of specific genes, such as the transcription factor ATF4, to promote cellular recovery. The central nexus of this pathway is the phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) by one of the four eIF2α kinases that sense specific cellular stressors. The heme-regulated inhibitor (HRI) is one of these kinases, and it was initially reported to be activated in response to heme deprivation. Nevertheless, further studies have established that cytosolic proteotoxicity, resulting from oxidative or osmotic stress, heat shock, and proteasome inhibition, is the predominant trigger for HRI to induce the ISR. Newly identified functions of HRI in innate immunity, proteostasis, and mitochondrial stress will be presented in this seminar. Indeed, HRI-mediated signaling defines a novel cytosolic unfolded protein response (cUPR) required for the proper formation of some innate immune signalosomes and the control of toxic protein aggregates, and this eIF2α kinase also serves as a relay for mitonuclear communication after a mitochondrial stress. "
