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SUMMARY:External Seminar "Bacterial nanotubes extend from a tubeosome orga
 nelle to establish an intercellular bridge" by Sigal Ben-Yehuda
DTSTART:20260615T120000Z
DTEND:20260615T130000Z
DTSTAMP:20260625T071700Z
UID:indico-event-431@indico.i2bc.paris-saclay.fr
CONTACT:paulo.tavares@i2bc.paris-saclay.fr
DESCRIPTION:Title: Bacterial nanotubes extend from a tubeosome organelle t
 o establish an intercellular bridge\nSpeaker: Sigal Ben-Yehuda\nAffiliatio
 n: Department of Microbiology and Molecular Genetics\, The Hebrew Universi
 ty of Jerusalem\, Israel\nAbstract: We have previously identified a novel 
 mode of bacterial communication mediated by nanotubes that bridge neighbor
 ing cells. We have demonstrated that nanotubes serve as conduits for inter
 cellular trade of metabolites\, antibiotic resistance proteins\, toxic pro
 teins\, and even non-conjugative plasmids\, thus playing a central role in
  bacterial physiology. However\, nanotube formation and dynamics have rema
 ined largely unexplored. By combining live-cell imaging with cryo-electron
  tomography\, we describe the biogenesis of nanotubes in Bacillus subtilis
 . We show that nanotubes form elaborate\, dynamic networks\, with extendin
 g nanotubes exhibiting multidirectional movement toward neighboring cells\
 , scanning their surface for minutes. This process culminates in nanotube 
 penetration and the establishment of an intercellular bridge. Nanotubes em
 erge within milliseconds from lipid-enriched sites representing a previous
 ly unrecognized membranous organelle\, which we term “tubeosome”\, loc
 ated in a periplasmic-like space beneath the cell wall. We provide evidenc
 e that tubeosomes comprise rolled nanotubes organized in a fire-hose-like 
 structure generated through vesicle chain fusion. Our study uncovers the t
 ubeosome as a novel bacterial organelle and provides the first real-time v
 isualization of intercellular bridge formation in bacteria.\n \n\nhttps:/
 /indico.i2bc.paris-saclay.fr/event/431/
LOCATION:B24-N2-315 (I2BC CNRS Gif)
URL:https://indico.i2bc.paris-saclay.fr/event/431/
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