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SUMMARY:External Seminar Matthieu Benoit "Diversity of mechanochemical cyc
 les in the kinesin superfamily revealed by cryo-EM"
DTSTART:20260728T120000Z
DTEND:20260728T140000Z
DTSTAMP:20260812T071800Z
UID:indico-event-476@indico.i2bc.paris-saclay.fr
DESCRIPTION:Speaker: Matthieu Benoit - IGDR\, Rennes\nTitle: Diversity of 
 mechanochemical cycles in the kinesin superfamily revealed by cryo-EM\nAb
 stract: Kinesins are ATP-dependent motor proteins that play essential role
 s in eukaryotic cells\, including organelle transport\, morphogenesis\, ce
 ll division\, and ciliary function. By coupling ATP binding and hydrolysi
 s to conformational changes in their motor domains\, kinesins generate mec
 hanical work that supports movement along microtubules and/or regulation 
 of microtubule dynamics. Kinesin-3 and kinesin-13 motors illustrate two co
 ntrasting specializations: kinesin-3 motors are motile\, whereas kinesin-1
 3 motors are non-motile microtubule depolymerases. Kinesin-8 motors are d
 istinctive in combining both activities\, moving processively along microt
 ubules while promoting microtubule-end depolymerization. Recent advances i
 n cryo-EM have enabled high-resolution visualization of kinesins on microt
 ubules throughout their ATPase cycles. This presentation will discuss how 
 cryo-EM\, together with single-molecule experiments\, provides an in-depth
  view of the mechanisms of kinesin-3\, kinesin-13\, and kinesin-8 motors\,
  and how distinct mechanochemical cycles support motility\, depolymerizati
 on\, or both.Invited by Sophie Zinn\n\nhttps://indico.i2bc.paris-saclay.fr
 /event/476/
LOCATION:B26-N2-000 (I2BC CNRS Gif)
URL:https://indico.i2bc.paris-saclay.fr/event/476/
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