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SUMMARY:External Seminar "Order in the Chaos: How Cells Navigate Broken Ge
 nomes" by Anjana Bradynarayanan
DTSTART:20260904T090000Z
DTEND:20260904T103000Z
DTSTAMP:20260812T071800Z
UID:indico-event-477@indico.i2bc.paris-saclay.fr
CONTACT:virginia.lioy@i2bc.paris-saclay.fr
DESCRIPTION:Speakers: Virginia LIOY\n\nTitle: Order in the Chaos: How Cell
 s Navigate Broken Genomes\nSpeaker: Anjana Bradynarayanan\nAffiliation: Na
 tional Centre for Biological Sciences\, Bangalore\, India\nAbstract: Infor
 mation essential for life is encoded within DNA\, yet this molecule is con
 stantly challenged by diverse sources of damage. Our research program asks
  how microbial cells regulate DNA damage repair in space and time\, using 
 high-resolution imaging to track replication\, recombination and repair in
 side individual cells.  In this talk\, I will focus on double-strand brea
 k repair by homologous recombination\, centred on homology search\, in whi
 ch a RecA nucleoprotein filament must locate a matching sequence within a 
 crowded genome. Our work shows that homology search is not a passive\, dif
 fusive scan but an actively organised process unfolding in two steps. Firs
 t the filament must encounter its candidates\, a problem of movement. We f
 ind that the SMC-like protein RecN acts as a DNA motor\, driving filaments
  in long-range\, back-and-forth sweeps across the cell\, with a conserved 
 DNA helicase an essential partner in this motion. A chance encounter must 
 then become a commitment\, and here the genome's own topology supplies the
  selectivity. RecA filaments overwhelmingly favour negatively supercoiled 
 targets\, so that supercoiling\, not mere proximity\, finally licenses a f
 aithful pairing. Together these pieces describe a coordinated apparatus fo
 r moving genetic information faithfully within a cell. Indeed\, the same r
 ecombination machinery can move information between cells as well\, and th
 e very processes that protect genetic information are also the ones that m
 ove and reshape it.\n \n\nhttps://indico.i2bc.paris-saclay.fr/event/477/
LOCATION:B22-N0-001 - Salle de Conférences (I2BC CNRS Gif)
URL:https://indico.i2bc.paris-saclay.fr/event/477/
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