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Description
Targeting of AIF/CHCHD4 complex, a key complex for nucleus-to-mitochondria communication and metabolism, for anti-cancer therapy
Abstract:
Abstract:
Metabolism reprogramming is a characteristic of many, if not all cancers, and may be targeted pharmacologically to fight intrinsic and acquired chemoresistance in cancer patients. With the aim to discover small molecules capable to decrease metabolic flexibility of cancer cells, we propose a novel class of chemically-modified flavonoids with the ability to bind to mitochondrial apoptosis inducing factor (AIF) and disrupt the AIF/ coiled-coil-helix-coiled-coil-helix domain containing 4 (CHCHD4) complex.
Dr Catherine Brenner is director of METSY - UMR 9018 CNRS Cancer biology and metabolism, Université Paris-Saclay, Gustave Roussy. She is a leading researcher in mitochondrial biology whose work focuses on mitochondrial signaling pathways, metabolic reprogramming, and cell death mechanisms in cancer. Her research has provided key insights into how mitochondrial dysfunction and bioenergetic alterations contribute to tumor progression and therapeutic response.
Organisé par
Club Mitochondrie - BioCell Department - Inge Kühl
